ACS Macro Letters出版了當代軟物質科學的所有領域的研究，其中大分子起著關鍵作用，包括納米技術、自組裝、超分子化學、生物材料、能源生成和儲存以及可再生/可持續材料。提交給美國化學學會的宏觀信件應該清楚地證明快速披露研究的關鍵要素是正當的。該雜志的范圍包括在聚合物科學和工程的所有領域廣泛關注的高影響研究，包括與聚合物科學相關的跨學科研究。隨著ACS Macro Letters的發布，所有與以前在大分子聚合物上發布的編輯器的通信都將以ACS Macro Letters的形式發布。

ACS Macro Letters publishes research in all areas of contemporary soft matter science in which macromolecules play a key role, including nanotechnology, self-assembly, supramolecular chemistry, biomaterials, energy generation and storage, and renewable/sustainable materials. Submissions to ACS Macro Letters should justify clearly the rapid disclosure of the key elements of the study. The scope of the journal includes high-impact research of broad interest in all areas of polymer science and engineering, including cross-disciplinary research that interfaces with polymer science.With the launch of ACS Macro Letters, all Communications to the Editor that were formerly published in Macromolecules will be published as Letters in ACS Macro Letters.