自1964年創(chuàng)刊以來，在生物分子的結(jié)構(gòu)-功能關(guān)系方面發(fā)表了許多原創(chuàng)研究論文;生物分子識別、蛋白質(zhì)-蛋白質(zhì)和蛋白質(zhì)- dna相互作用;基因克隆、基因工程、基因組分析、基因定位、基因表達、載體、基因治療;藥物靶向、藥物設(shè)計;遺傳疾病的分子基礎(chǔ);構(gòu)象研究、計算機模擬、新型DNA結(jié)構(gòu)及其生物學意義、蛋白質(zhì)折疊;酶的結(jié)構(gòu)、催化機理、調(diào)控;膜生物化學、轉(zhuǎn)運、離子通道、信號轉(zhuǎn)導、細胞-細胞通訊、糖生物學;受體、抗原抗體結(jié)合、神經(jīng)化學、衰老、凋亡、細胞周期控制;激素、生長因子;致癌基因、宿主-病毒相互作用、病毒組裝和結(jié)構(gòu);中間代謝，疾病過程的分子基礎(chǔ)，維生素，輔酶，載體蛋白，毒理學;植物與微生物生物化學;生物系統(tǒng)中的表面力、膠束和微乳液、膠體、電現(xiàn)象等。征求同行對當代生物化學和生物物理學的主題和方法的評論文章，形成了IJBB的一個重要特點。

Started in 1964, this journal publishes original research articles in the following areas: structure-function relationships of biomolecules; biomolecular recognition, protein-protein and protein-DNA interactions; gene-cloning, genetic engineering, genome analysis, gene targeting, gene expression, vectors, gene therapy; drug targeting, drug design; molecular basis of genetic diseases; conformational studies, computer simulation, novel DNA structures and their biological implications, protein folding; enzymes structure, catalytic mechanisms, regulation; membrane biochemistry, transport, ion channels, signal transduction, cell-cell communication, glycobiology; receptors, antigen-antibody binding, neurochemistry, ageing, apoptosis, cell cycle control; hormones, growth factors; oncogenes, host-virus interactions, viral assembly and structure; intermediary metabolism, molecular basis of disease processes, vitamins, coenzymes, carrier proteins, toxicology; plant and microbial biochemistry; surface forces, micelles and microemulsions, colloids, electrical phenomena, etc. in biological systems. Solicited peer reviewed articles on contemporary Themes and Methods in Biochemistry and Biophysics form an important feature of IJBB.